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Cancer Genetics In the last decade, researchers have made important discoveries about specific genes and their contribution to familial cancer risks. Though the majority of all cancers occur sporadically, a growing number of families are being recognized as having genetic changes (mutations) that predispose them to certain types of cancer. Genetic testing is available for families who have histories of breast, ovarian, colorectal, and other rare cancers. OriGens works with your doctor to identify these families and provide recommendations for further medical management. Genetic testing for susceptibility to cancer is a unique process, unlike other routine medical tests. Adequate discussion regarding the nuances of genetic testing should be covered by a health care provider knowledgeable and aware of these intricacies. OriGens has tested hundreds of families and recognizes that though the test itself is simple, great care must be taken at communicating these important results. Patients who meet one or more of the following categories would benefit from a Genetic Risk Assessment and consultation with OriGens: Breast or Ovarian Cancer History Personal or family history of breast cancer diagnosis prior to the age of 50 Personal or family history of ovarian cancer diagnosis prior to the age of 50 History of Male relative with breast cancer at any age Family history of breast and/or ovarian cancer and Eastern European (Ashkenazi) Jewish descent Breast and Ovarian cancer in the same individual in a family Personal or family history of breast cancer in both breasts (bilateral breast cancer) Known BRCA 1/2, PTEN, P53 mutation in the family Colon Cancer History Personal or family history of colon cancer diagnosis prior to the age of 50 Two or more colon cancer diagnoses at any age on the same side of the family Personal or family history of colon cancer diagnosis with diagnosis of associated cancer including: ovarian, uterine (endometrial), ureter, small bowel, stomach, brain Family history of polyposis Known APC, MYH, MSH1, MLH2, MSH6 mutation in the family Less Common Cancer History Sarcoma diagnosis prior to the age of 45 Glioma or childhood adrenal cortical carcinoma Complicated patterns of multiple cancer at young ages

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